To describe the prevalence of childhood adverse events (CAEs) among methamphetamine-dependent men and women, and assess the relationship of cumulative CAEs to health problems. Data for 236 men and 351 women were analyzed assessing CAEs. Dependent variables included 14 self-reported health problems or psychiatric symptom domains. Mental health was assessed via the Mini-International Neuropsychiatric Interview. Medical conditions were collected using the Health Status Survey. Women reported more cumulative exposure to CAEs than men (28% vs. 13%, p less than 0.01). Regressions showed the impact of CAEs on health is strong for both men and women. Yet, women were more likely than men to have 7 out of 14 health problems, independent of their reported abuse (ranging from a positive OR for suicidality = 1.63 to a positive OR for bladder/bowel disease = 6.09). Substance abuse treatment programs should prioritize individual treatment plans and enhance multi-agency collaborations to provide referrals and community networks that offer clients appropriate trauma-based psychiatric and/or medical treatment.