The objective of the present work was to implement a teaching system useful in modeling and simulation of biotechnological processes. The interactive system is based on applications developed using 20-sim modeling and simulation software environment. A procedure for the simulation of bioprocesses modeled by bond graphs is proposed and simulators containing biochemical bond graph elements are designed. These simulators are organized in libraries that exploit the modularity of the method, very useful for master students, who will be able to model and simulate complex bioprocesses. In order to evaluate the learning performance of this teaching system, an analysis was performed using a pre-test/post-test scenario, with a multiple-choice knowledge test. (Contains 3 tables and 12 figures.)