In recent years digital technologies, such as tablet personal computers (TPCs), have become an integral part of a school's infrastructure and are seen as a promising way to facilitate students' learning processes. This study empirically tested a theoretical model derived from the technology acceptance model containing key constructs developed in previous research on the acceptance of technological innovations. On the basis of the research model, it was hypothesized that students' acceptance of tablet PCs could be explained by key constructs and could be distinguished in organizational, individual, and technological factors. The survey research was conducted in three German middle schools, involving a total of 120 students. Overall, participants' attitude toward the TPC positively predicted their behavioral intention to use the TPC and as such had the strongest direct influence. The findings emphasize the importance of understanding factors affecting students' attitudes in order to manage and influence the integration of TPCs in schools.