This article contends that the third generation of cultural-historical activity theory as forwarded in Yrjo Engestrom's version of expansive learning offers the people of South Africa a framework within which to practically realise the objective of a more culturally inclusive and relevant education. By recognising and harnessing the divergent and even opposing principles and values within indigenous and modern western knowledge traditions, the expansive learning framework provides a vehicle for implementing the kind of education which has been conceived of by such policies as the country's Indigenous Knowledge Systems (IKS) Policy and the Science-IKS curriculum. It is argued that this approach has the potential to take the indigenous knowledge initiatives beyond their current impasse in policies and bureaucratic institutions by generating new forms of cultural activity from the very conflicts inherent in the project. The principles of object orientation, multi-voicedness, historicity, contradictions as a driving force and expansive transformation are outlined at the level of interacting western and IKS, but shown to be operationalised through learning and research activity at a local level in classrooms and communities so that they generate new practices and policies from people's daily activity. (Contains 1 figure.)