Purpose: The model-based quantitative analysis of high-speed videoendoscopy (HSV) data at a low frame rate of 2,000 frames per second was assessed for its clinical adequacy. Stepwise regression was employed to evaluate the HSV parameters using harmonic models and their relationships to the Voice Handicap Index (VHI). Also, the model-based HSV parameters were compared with those using conventional analysis techniques. Method: Eight pairs of HSV recordings of vocal folds before and after surgery for benign lesions were investigated. Five glottal area waveform features--fundamental frequency (F0), open quotient (OQ), speed index (SI), relative glottal gap (RGG), and harmonics-to-noise ratio (HNR)--were measured using model-based and conventional approaches. The statistical analyses were conducted on the mean (M) and standard deviation (SD) of the feature measurements over 1 s during sustained phonation. Results: Two model-based HSV parameters, OQ M (? = 0.67) and HNR M (? = -0.56), were selected and explained 55% of the VHI variation. The conventional techniques yielded a regression model with OQ SD (? = -0.60) and F0 SD (? = 0.44), explaining 61% of the VHI variation. Conclusions: Although the selected model-based HSV parameters explained less variation in the VHI than the conventionally computed HSV parameters, the behaviors of the model-based parameters were more consistent with expectations and theory than the conventional analysis techniques.