The results of the twelfth annual EDUCAUSE Current Issues Survey reflect the everyday balancing act that IT leaders need to perform. Many of the issues show the need for continued and thoughtful long-range planning, yet new issues have also risen quickly to the top, requiring nimbleness in both thought and act. Administered by the EDUCAUSE Current Issues Committee, the electronic survey was conducted in December 2010. Survey participants--typically CIOs of EDUCAUSE member institutions--were asked to select the five most-important IT issues out of a selection of twenty-seven in each of four areas: (1) issues that are critical for strategic success; (2) issues that are expected to increase in significance; (3) issues that demand the greatest amount of the campus IT leader's time; and (4) issues that require the largest expenditures of human and fiscal resources. This article presents the top-ten IT-related issues in terms of strategic importance to the institution, as revealed by the twelfth annual EDUCAUSE Current Issues Survey. (Contains 7 notes.)