The purpose of this study was to describe and evaluate a promising program model, the Joven Nobel curriculum, for Latino male adolescents that promotes positive youth development and addresses prevention of a number of risk-related sexual behaviors within a cultural context. A quasi-experimental design was used that included a pre- and posttest assessment of 683 adolescent males. Results revealed that youth exposed to the 10-week curriculum had significant increases in knowledge and decrease in behavior related to high risk sexual behaviors. Out of eight scale measures (ATSS, Perceived Risk, HIV Knowledge, CAPS: Talk, CAPS: Comfort Talk, CAPS: Cool Sex, ATA, Cultural Esteem, and Hombres Con Palabra) seven yielded a significant and positive outcome results. The curriculum appears effective in shaping youth's attitudes and beliefs about high-risk sexual behaviors. (Contains 4 tables and 1 footnote.)