In this study, the authors compared differences in sexual risk attitudes and intentions for three groups of youth (experimental program, n = 90; attention control, n = 80; and nonparticipant control, n = 634) aged 12-14 years. Two student groups participated with their parents in programs focused on strengthening family interaction and prevention of sexual risks, HIV, and adolescent pregnancy. Surveys assessed students' attitudes and intentions regarding early sexual and other health-risk behaviors, family interactions, and perceived parental disapproval of risk behaviors. The authors used general linear modeling to compare results. The experimental prevention program differentiated the total scores of the 3 groups (p less than 0.05). A similar result was obtained for student intentions to avoid sex (p less than 0.01). Pairwise comparisons showed the experimental program group scored higher than the nonparticipant group on total scores (p less than 0.01) and on students' intention to avoid sex (p less than 0.01). The results suggest this novel educational program involving both parents and students offers a promising approach to HIV and teen pregnancy prevention. (Contains 6 tables.)