This report summarizes the findings of a conference that examined the problem of Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS) among street and homeless youth. Street and homeless youth, by virtue of their circumstances and the behaviors they engage in, are at great risk of becoming infected with HIV, the virus that causes AIDS. The following guidelines should be considered by program planners: (1) an HIV education program must be part of a broader effort to address the needs of street and homeless youth; (2) individual characteristics must be acknowledged and addressed through programmatic adjustments; (3) a credible messenger is crucial; (4) mesages must be simple and straightforward so that they can be delivered through many different programs in limited amounts of time; and (5) service providers must communicate the dangers of HIV infection for street and homeless youth to the broader community. Health educators must use publicity, outreach, and peer education to address the myths and misconceptions about HIV infection and AIDS. The following model programs exemplify the maximization of resources through collaboration: (1) Project Risk Reduction (Los Angeles, California); (2) Project START (Seattle, Washington); and (3) Project ASAP (San Francisco, California). Policy recommendations are included. One table of statistical data, two charts, and a list of resource organizations are also included. The conference agenda, a list of participants, and a list of 24 references are appended. (FMW)