In this essay I argue that the primary role that Gloria Anzaldua creates for herself as a writer and activist is that of the curandera of conquest, the healer of "la herida abierta" (the open wound) created by the borders imposed by capitalism, nationalism, imperialism, sexism, homophobia, and racism. After examining Anzaldua's "Prietita and the Ghost Woman" as both an illustration (in content) and an example (in enactment) of her practice as a curandera, I provide a brief overview of curanderismo and key developments in the theories of decolonization within global indigenous studies since the turn of the twenty-first century. I read Anzaldua's decolonizing work as a companion to this recent decolonization move within indigenous theory and practice.