There is emerging evidence to suggest community-based interventions can change community-wide behaviors and attitudes toward cardiovascular health. This article describes a partnership between an academic institution and a community nonprofit organization to develop and implement a cardiovascular health promotion program targeting at risk high school adolescents in underserved communities. Program implementation will begin in several schools during the 2014-15 academic year. We will evaluate the program's impact on student knowledge, attitudes, and behaviors related to CV health. Secondary goals are inspiring high school teachers' innovative approaches to teaching biology and health, and fostering health and science career aspirations among students.