Changes in the health care arena and within the specialty of group work are contributing to the increased utilization of groups in health care settings. Psychoeducational, theme, and interpersonal therapy groups are highlighted for their contributions to treating challenging health conditions. An understanding of the evolution of these group modalities, distinguishing their core features, and applying the fundamentals of group development assist in the development of group interventions to treat a wide range of conditions. Theme groups appear to be emerging as a more prominent group modality across a variety of health care settings to address challenging health conditions. (Contains 1 table.)