Brief interventions based on motivational interviewing (MI) are emerging as effective strategies for behavior change in college students. However, implementation of MI-based brief interventions may be challenging in the college health environment, and their practicality is controversial. The author explored college health clinicians' perspectives on the use of MI brief interventions in a college health study to reduce alcohol harms among high-risk college students. The author describes the challenges, benefits, and practicality of using this health promotion strategy in college health. Although MI-based brief interventions may be adapted and implemented and are beneficial in the college health setting, clinician education and further research is warranted.