This study examined the validity of the Klonoff and Landrine Illness-Belief Scale when applied to Latino college students (n = 156; 34% male, 66% female) at high risk for future diabetes onset. Principal factor analysis yielded four significant factors--emotional, folk beliefs, punitive, gene/hereditary--which accounted for 64.5% of variance and provided a culturally relevant Latino perspective of the causes of diabetes. Additional analyses by age, gender, immigrant status, and psychological acculturation revealed significant differences by age on the emotional and folk illness factors and a negative correlation between assimilation and endorsement of the emotional factor. The implication of these four illness factors for predicting health-related behaviors and health outcomes among young Latinos was discussed as were recommendations for future research. (Contains 2 tables.)