This article elaborates on the centrality of interventions for social work practice and the importance of understanding the effects of interventions for a more efficient, harmless, transparent, and ethical social work practice. Low-bias research designs and meta-analyses are important means of generating the best possible evidence on what works in social work practice. An evidence-based practice model is promising in terms of translating and implementing scientific evidence that is uncertain, volatile, and incomplete and might be difficult to access.