This paper explores a conceptualization of how factors impact activities of daily living (ADL) and participation from the perspective of persons with disability. This study identified what, and how, factors perceived by participants affect their daily activities, to better inform reporting of scores obtained on measures of ADLs and participation such as the Barthel Index and the Participation Scale. Grounded theory methodology was used to conceptualize a model, employing semi-structured interviews guided by categories of the above measures. Eight themes emerged from 24 participants, resulting in conceptualization of the successful adaptation model, which demonstrates relationships amongst factors, activities, and participation. Health professionals can use this model to assist persons with disability achieve desired goals. (Contains 1 table and 2 figures.)