The manipulation of the natural world in the form of plant materials to design, control, and grow desirable agricultural commodities was central to the establishment and advancement of civilization. Modern developments in genetically modified organisms (GMOs or biologically engineered foods) can trace their origins to macro practices developed and utilized over millennia. By learning about apple grafting, students can be introduced to the pros and cons of agriculture technology, food science, and biotechnology through hands-on, applied learning, fostering technological literacy, and demystifying biological engineering concepts in the process. This article discusses: (1) why grafting is necessary to preserve an original fruit; (2) how to graft; (3) cultural/ethical implications; (4) legal implications; (5) environmental concerns; and (6) uses in education, including suggested lessons that integrate STEM activities.