The Social Responsiveness Scale (SRS) is currently being used in clinical and genetic studies of autism as both a screener and as a quantitative measure of autistic traits. This article assesses the influence of nonspecific factors on SRS scores to aid researchers in their interpretations of these scores. In their commentary, Constantino and Frazier (2013) argued that the strong influence of behavior problems on the SRS represents the overlap between neuropsychiatric syndromes, and that behavioral symptoms reflected in SRS scores "might actually be caused by the autistic syndrome". They cited evidence for substantial overlap in genetic associations between ASD, ADHD, and other child psychiatric disorders. The concern of the author's of this article, however, is that if scores on a measure do not distinguish between general behavior problems and autism symptoms, questions about overlap cannot even begin to be answered. Moreover, what was not noted in the commentary was the fact that the author's found equally large effects of behavior problems and smaller effects of social competence on SRS scores in typical siblings, who did not have ASD. The goal in the original article was to determine the influences of non-specific factors known to affect scores on other ASD measures in order to provide more informed interpretations of SRS scores.