Colleges and universities are increasingly spending resources to become more global. For more than 20 years, the author has participated in, or served as a consultant to, the internationalization efforts of a broad range of institutions--research universities, regional state universities, private liberal-arts colleges, and community colleges--and has witnessed a variety of approaches and outcomes. Some institutions experienced significant, transformative change, while others merely developed documents that were forgotten within months of their unveiling. At its best, internationalization is a campuswide undertaking that challenges institutions to view their fundamental missions from a new perspective, to rethink what is learned and how, to redefine their boundaries, and to consciously extend their global reach and impact. To do so, colleges and universities should create a learning environment that systematically gives faculty members and students opportunities to translate knowledge into action in the real world. That requires: (1) articulating a bold vision; (2) investing in the vision; and (3) sustaining the vision. Comprehensive internationalization, when well conceived and well executed, can energize and focus an entire campus toward a common goal, and shape its character and reputation for decades to come.