This study examined patterns of intra- and interracial best friendships during middle school and their associations with social and emotional well-being. We hypothesized that intraracial friendships would be beneficial for racial or ethnic minority youth because such relationships provide protection and solidarity in a discriminatory society. Results revealed that most youth had only intraracial best friends during middle school, but 38% had at least one interracial best friend. Associations between interracial best friendships and well-being varied by racial group; Black and Asian American youth with only interracial best friends reported lower emotional well-being than those with only intraracial best friends. Additionally, intraracial best friendships were associated with higher conflict than interracial best friendships, especially for Black and Latino youth. (Contains 4 tables and 1 figure.)