In recent decades the investigation of framing effects has become the foremost studied phenomenon of rational/irrational decision making. Two experiments were conducted to determine whether the functional specializations of the left and the right hemispheres would produce different responses to a traditional framing task. In Experiment 1, a behavioral task of finger tapping was used to induce asymmetrical activation of the respective hemispheres. In Experiment 2, a monaural listening procedure was used. In both experiments, the predicted results were found. Framing effects were found when the right hemisphere was selectively activated whereas they were not observed when the left hemisphere was selectively activated. The results are interpreted in light of a dual-processing approach of decision-making.