Observations and experiments with mice, developed and tested at the Pennsylvania Advancement School with underachieving boys in grades seven and eight, are described in this teachers' guide which includes copies of student worksheets for exercises needing them. In addition to lists of materials and procedural suggestions, ideas for guiding discussion to develop parallels with humans are provided for each exercise. The exercises are "Taming the Mouse,""Observing Individual Mice,""Experiments with Individual Mice (responses to stimuli, food preferences, agressive behavior),""Training the Mouse to Walk a Tightrope," and "Observing Groups of Mice (social organization; responses to strange mice, cats, loud tapping, food and water deprivation, and overcrowding)." (AL)