A method to fabricate microfluidic devices and an experimental protocol to model intravascular gas embolism for undergraduate laboratories are presented. The fabrication process details how to produce masters on glass slides; these masters serve as molds to pattern channels in an elastomeric polymer that can be adhered to a substrate, resulting in a microfluidic device. This fabrication technique can produce various channel configurations. The gas embolism experiment demonstrates fundamental fluid dynamics phenomena in model vasculature.