This longitudinal study tested the degree to which an individual characteristic, psychological flexibility, and a work organization variable, job control, predicted ability to learn new skills at work, job performance, and mental health, amongst call center workers in the United Kingdom (N = 448). As hypothesized, results indicated that job control, psychological flexibility, and the synergistic interaction between the two, predicted people's ability to learn a new computer software program, as well as their mental health and job performance, which was objectively measured. Discussion focuses on the implications of these, and previous findings, for organizational behavior.