The emerging field of mind, brain, and education (MBE) is grappling with core issues associated with its identity, scope, and method. This article examines some of the most pressing issues that structure the development of MBE as a transdisciplinary effort. Rather than representing the ongoing debates in MBE as superficial squabbles to eventually be "overcome," this article argues that the politics of MBE language, discourse, and validity suggest profound epistemological differences that transcend a traditional interdisciplinary approach. Instead, MBE would benefit from a transdisciplinary approach that contextually accords equal and differential weight to a range of knowledge inputs from education studies, neuroscience, and other academic and practitioner spheres beneath the broad umbrella of MBE. Specifically, this article suggests that some of the key tasks for those involved in MBE studies require a transdisciplinary approach to knowledge translation and knowledge development.