Despite their differences in place and time, the woman-centered Chilean poet Gabriela Mistral and the Chicana lesbian feminist writer Gloria Anzaldua both looked to a transnational intellectual American history that frequently connected discourses of esotericism, indigenismo, and mestizaje. My comparative approach shows how both women used these discourses as a way to reconceptualize the subjectivity of the queer, indigenous-identified mestiza in a modern world. Notions of a new cosmic consciousness achieved via racial synthesis echo through twentieth-century Latin American and Chicana/o texts; theosophical ideas about race and spirit were deeply influential in Mistral's writing and beliefs, and theosophy in turn informed the New Age feminist spirituality that helped shape Anzaldua's work. Outlining a history of the connections between these esoteric beliefs and those of mestizaje, and indigenismo, I show how Mistral and, later, Anzaldua inherited and rewrote these notions by incorporating them into a queer sensibility.