In April 2005, the International Association for Marriage and Family Counseling's yearly Distinguished Speakers series at the American Counseling Association Conference featured a presentation on family counseling with Mestizo/Latino immigrants. A panel composed of Latino counseling professionals representing varied Mestizo backgrounds discussed their personal and professional experiences surrounding the Mestizo/Latino diaspora. This article discusses population definitions, contextual variables, and demographics regarding Mestizos/Latinos, along with life transition issues and ethnic-heritage themes. A psychohistorical approach to family counseling is presented, and illustrative vignettes, including personal anecdotes by the conference presenters/authors, are provided. Recommendations for practice are offered. (Contains 1 figure.)