Meta-analysis was used to comprehensively summarize the relationship between dispositional variables and both directions of work-family conflict. The largest effects detected were those associated with negative affect, neuroticism, and self-efficacy; all were in expected directions. In general, negative trait-based variables (e.g., negative affect and neuroticism) appear to make individuals more vulnerable to work-family conflict, while positive trait-based variables (e.g., positive affect and self-efficacy) appear to protect individuals from work-family conflict. In addition, the different dimensions of work-family conflict (time, strain, and behavior) exhibited different patterns of relationships with several of the dispositional variables. No moderating effects were found for sex, parental status, or marital status. Results support the notion that dispositions are important predictors of work-family conflict. (Contains 7 tables.)