This study investigated interrelations between conflict and facilitation in work and family domains, with spousal, managerial, and collegial social support serving as antecedents, and professional vigor and burnout as outcomes. Participants were 322 female, married teachers. Regression analyses revealed complex relations between conflict and facilitation, and different patterns of association in the work and family domains. Only managerial support predicted conflict and facilitation relations. Work-to-family (W[right arrow]F) and family-to-work (F[right arrow]W) conflict predicted burnout. Results suggest that conflict and facilitation are distinct constructs and they underscore the importance of working with managers to enhance their ability to promote employees' health. (Contains 3 tables.)