ERIC Number: EJ1044400
Record Type: Journal
Publication Date: 2014-Aug
Pages: 9
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0002-7685
EISSN: N/A
Drug-Resistant Tuberculosis: A Genetic Analysis Using Online Bioinformatics Tools
Taylor, Jessica M.; Davidson, Rebecca M.; Strong, Michael
American Biology Teacher, v76 n6 p386-394 Aug 2014
Tuberculosis (TB) continues to be a serious global health problem, resulting in >1.4 million deaths each year. Of increasing concern is the evolution of antibiotic resistant strains of the bacterium that causes TB. Using this real-world scenario, we created a 90-minute activity for high school or undergraduate students to use online bioinformatics tools to detect single-nucleotide polymorphisms (SNPs) between a wild-type and a variant "Mycobacterium tuberculosis" gene that could confer resistance to a commonly used TB antibiotic, rifampin. Students write a scientific explanation, providing evidence and reasoning, to support their claim of antibiotic resistance or susceptibility. The entire lesson can be found online at http://www.stronglab.org/taylor.
Descriptors: Biology, Information Science, Public Health, Communicable Diseases, Drug Therapy, Vignettes, Simulation, High School Students, Undergraduate Students, Secondary School Science, College Science, Concept Formation, Teaching Methods, Science Activities
University of California Press. 2000 Center Street Suite 303, Berkeley, CA 94704. Tel: 510-643-7154; Fax: 510-642-9917; e-mail: customerservice@ucpressjournals.com; Web site: http://www.ucpressjournals.com/journal.php?j=abt
Publication Type: Journal Articles; Reports - Research; Tests/Questionnaires
Education Level: High Schools; Secondary Education; Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID/NIH)
Authoring Institution: N/A
Grant or Contract Numbers: R25AI080566