In this article, the authors describe a concerted, long-term effort by academic women chemists to provide mentoring and training for their colleagues to survive and change the negative climate of their profession and to develop successful careers in spite of these barriers. Data came from records kept by the group, observations of their activities, and extensive reflections of key participants. Concepts from the social science literature regarding successful organizations are applied to the analysis. Important elements identified are strong and consistent leadership, use of social networks to maintain a diverse and committed membership, using data to develop and change programs, and an organizational culture that supports norms promoting deliberative task orientations and a supportive socioemotional climate.