Educators in evidence-based medicine (EBM) have noted that the core set of epidemiological concepts outlined in standard sources are sometimes put to use as oversimplified checklists for the appraisal of research reports. In this article, the authors present the Graphic Appraisal Tool for Epidemiology which was designed as a way combat, by visual means, a formulaic approach to appraising the scientific literature. Furthermore, the authors define and deconstruct the GATE frame, exemplify its use by applying it to a widely known study in child and adolescent psychiatry (Treatment for Adolescents With Depression Study [TADS], 2004), note the core appraisal and epidemiology principles that are highlighted through its use, and propose applications for the GATE in clinical, teaching, and research settings. (Contains 1 table and 1 figure.)