Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the analytic framework for understanding how the external and internal neurobiological environments and mechanisms interact. Brady's approach offered synthesis as well as analysis. He embraced Findley's approach to constructing multioperant behavioral repertoires that found their way into designing environments for astronauts as well as studying drug effects on human social behavior in microenvironments. Brady created translational neurobehavioral science before such a concept existed. One of his most lasting contributions was developing a framework for ethical decision making to protect the rights of the people who participate in scientific research. (Contains 3 figures and 1 footnote.)