The purpose of this safety manual is to provide a resource to help manage and minimize potential risks in science classrooms where students spend up to 60% of instructional time engaged in hands-on activities. Information on general laboratory safety, science equipment safety, safety with plants, safety with animals, safety with chemicals, field trips, safety equipment, first aid, and legal aspects of safety is included. General guidelines are provided and specific topics are discussed within each section. For example, in the section on science equipment safety, specific guidelines are given for handling glassware, thermometers, heat sources, the sun, lasers, model rockets, batteries, and electrical equipment. (DDR)