Although known for its distinctive food-related behaviors, Prader-Willi syndrome is a multisystem disorder with genetic, developmental, and behavioral features. Two separate and distinct eating disorders are noted: initial feeding difficulties and failure to thrive, and later overeating. Additional outcomes observed with this disorder include hypotonia, obesity, developmental/cognitive disabilities, and significant maladaptive behaviors. Symptoms vary in complexity across age and individuals. This necessitates multidisciplinary approaches to interventions across the life span to address medical, developmental, and behavioral issues. School psychologists have a vital role to play in assessment and consultation for individuals with this syndrome, their families, and school staff. (Contains 1 table.)