This study purports that parental rejection and warmth are critical to the development of adolescent drug use, and investigates a model that also considers children's vulnerability and deviant peer affiliations. It tests mediation through the proximal risk factor of deviant peers. Poisson growth curve modeling was used to examine participants from the Canadian National Longitudinal Survey of Children and Youth (NLSCY; N = 2194) over 4 waves. Results indicated that parental rejection was positively related to drug use, whereas parental warmth was negatively related to it. Both effects were significant when child ADHD symptoms were taken into account. Parental rejection and warmth had differential effects over time. Deviant peer affiliations were positively associated with drug use, did not have a differential influence over time, and did not mediate the other effects. There was significant between-individual (level 2) variability in drug use. Results are discussed in light of adolescent perceptions of parent-child relationships.