A microcomputer can be used in many different ways to assist people with disabilities. A computer's usefulness for a given individual is determined by the computer applications that are needed and by the specific problems the disability presents. In general, there are currently three ways that people with disabilities can use a microcomputer: (1) Many special software programs that run on standard computers have been written or adapted specifically for use by individuals with physical disabilities. They include communication and writing programs, word processing programs, motor training games, educational software, and therapy and assessment programs. (2) The operating system of a computer can be modified to accommodate special adaptations in the input or output process and to increase the rate of input. Standard software can then be used. (3) Hardware modifications can also enable disabled individuals to use standard software. These adaptations consist of simple modifications to the keyboard, disk drives, or computer screens, and connection of special alternate keyboards, disk drives, or alternate displays. A list of information sources on hardware and software developments concludes the paper. (JDD)