The EDUCAUSE Current Issues Committee, whose members review and recommend the set of IT issues to be presented each year, conducted a Web-based survey in December 2005 to identify the five of thirty-one IT issues in each of four areas: (1) issues that are critical for strategic success; (2) issues that are expected to increase in significance; (3) issues that demand the greatest amount of the campus IT leader's time; and (4) issues that require the largest expenditures of human and fiscal resources. This article describes the top-ten issues that IT leaders identified as the most important for their institutions to resolve for strategic success. These issues include: (1) Security and Identity Management; (2) Funding IT; (3) Administrative/ERP/Information Systems; (4) Disaster Recovery/Business Continuity; (5) Faculty Development, Support, and Training; (6) Infrastructure; (7) Strategic Planning; (8) Governance, Organization, and Leadership; (9) E-Learning/Distributed Teaching and Learning; and (10) Web Systems and Services. (Contains 16 notes.)