Historically, few women pursue studies or careers in science. In an effort to determine factors that relate to a scientific career choice, this research examines differences between sexes and among majors in 180 males and females in biological, physical science, and nonscience college majors. Nonscience majors mostly included female language students and male business students. The variables of spatial ability, mathematical ability, Jungian personality type, and masculinity and femininity were measured through a series of tests. The data indicate among other findings that males preferred to make decisions based on logical analysis and females based on personal values; science majors had higher mathematics scores than nonscience majors mostly due to the scores of physical science majors; no difference existed in the mathematics scores of biological and nonscience majors; science majors had the scientific personality and a positive attitude toward science; nonscience majors had the nonscientific personality and a negative attitude; males, and female physical science majors had masculine characteristics; all female nonscience majors had feminine characteristics; and female biological majors were predominantly feminine. (DC)