Context: Diabetes mellitus and its complications disproportionately affect minority citizens in rural communities, many of whom have limited access to comprehensive diabetes management services. Purpose: To explore the efficacy of combining care management and interdisciplinary group visits for rural African American patients with diabetes mellitus. Methods: In the intervention practice, an advanced practice nurse visited the practice weekly for 12 months and facilitated diabetes education, patient flow, and management. Patients participated in a 4-session group visit education/support program led by a nurse, a physician, a pharmacist, and a nutritionist. The control patients in a separate practice received usual care. Findings: Median hemoglobin A1c (Hb[subscript A1c]) was not significantly different at baseline in the intervention and control groups but was significantly different at the end of the 12-month follow-up period (P less than 0.05). In the intervention group, median HbA1c at baseline was 8.2 plus or minus 2.6%, and median (Hb[subscript A1c]) at an average follow-up of 11.3 months was 7.1 plus or minus 2.3%, (P less than 0.0001). In the control group, median (Hb[subscript A1c]) increased from 8.3 plus or minus 2.0% to 8.6 plus or minus 2.4% (P less than 0.05) over the same time period. In the intervention group, 61% of patients had a reduction in (Hb[subscript A1c]), and the percentage of patients with a (Hb[subscript A1c]) of less than 7% improved from 32% to 45% (P less than 0.05). Conclusions: These findings suggest that a redesigned care management model that combines nurse-led case management with structured group education visits can be successfully incorporated into rural primary care practices and can significantly improve glycemic control.