The Center for Epidemiologic Studies-Depression Scale (CES-D) is among the most widely used depression screening measures. Existing research suggests a higher-order factor structure of responses among older adults (factors labelled "depressive affect," "absence of well-being," "somatic symptoms," and "interpersonal affect," each loading upon a second-order depression factor). The current study extends this research to ascertain whether this structure is equivalent (or invariant) between the English and French versions of the CES-D. Findings suggest that the number and relative contribution of each factor is similar for both language groups. Furthermore, interpretation of CES-D items is statistically indistinguishable for 16 of 20 items within this randomly identified, national sample of caregivers of persons with dementia. Results of this study support the higher-order factor structure of this measure and provide data in support of the reliability of responses. Furthermore, findings support the use of the CES-D in cross-cultural and comparative research with English- and French-speaking adults. (Contains 2 figures.)