This study examined whether a transactional interpersonal life stress model helps to explain the continuity in depression over time in girls. Youth (86 girls, 81 boys; M age = 12.41, SD = 1.19) and their caregivers participated in a three-wave longitudinal study. Depression and episodic life stress were assessed with semistructured interviews. Path analysis provided support for a transactional interpersonal life stress model in girls but not in boys, wherein depression predicted the generation of interpersonal stress, which predicted subsequent depression. Moreover, self-generated interpersonal stress partially accounted for the continuity of depression over time. Although depression predicted noninterpersonal stress generation in girls (but not in boys), noninterpersonal stress did not predict subsequent depression. (Contains 2 footnotes, 2 tables, and 2 figures.)