This study aims to evaluate the predictive validity of the Children's Depression Inventory items for major depression disorder (MDD) in an outpatient clinic sample of Puerto Rican adolescents. The sample consisted of 130 adolescents, 13 to 18 years old. The five most frequent symptoms of the Children's Depression Inventory that best predict the presence of MDD were "I worry about others' aches and pains," "I don't have any friends," "I have to push myself to do my schoolwork," "I have trouble sleeping every night," and "I do very badly in subjects I used to be good in." Results demonstrated that the symptoms that best predict MDD in Puerto Rican adolescents are not necessarily the ones commonly described as characteristic of the disorder. (Contains 4 tables.)