As Baby Boomers reach 65 years of age and methods of studying older populations are becoming increasingly varied (e.g., including mixed methods designs, on-line surveys, and video-based environments), there is renewed interest in evaluating methodologies used to collect data with older persons. The goal of this article is to examine data-collection methodologies commonly used with older persons (closed-ended, structured surveys with standardized scales, performance-based measures, secondary data sets, open-ended interviewing, grounded theory, and ethnographic work) to illustrate issues arising from the use of each research design with older adults in real-life settings. Experiences from five studies are included to show the potential role of normative age-related sensory and functional changes as well as the role of age and cohort upon method. Specific guidelines are provided about how to improve existing data-collection methods for older persons and ways to improve selection of methodologies for use in future research on aging.