The article deals with the interplay between learning analytics and massive open online courses (MOOCs) and provides a conceptual framework to situate ongoing research in the MOOC and learning analytics innovation cycle (MOLAC framework). The MOLAC framework is organized on three levels: On the micro-level, the data collection and analytics activities are focused on individual reflection and individual prediction. On the meso-level, data from several open courses are combined to support benchmarking and to create insights about behaviour of groups of learners rather than the individual. These insights can inform the institution to adapt their educational model. On the macro-level of the framework, cross-institutional learning analytics enables to develop learning and teaching interventions that can be tested in a cluster of educational organizations to analyse the impact of these interventions beyond contextual factors. The article proposes four areas of future activities that are needed to enable the MOLAC framework. These are the standardization of the description of the educational design of MOOCs, data sharing facilities across institutions, joint policymaking and ethical guidelines and last but not least standardized evaluation approaches.