This annotated bibliography of research articles pertaining to the use of computer-assisted instruction (CAI) in the development of reading comprehension skills in students of all ages and abilities is introduced by brief statements of the problem addressed and the purpose, organization, and limitations of the study. A glossary is also provided. Ten of the 22 research articles are concerned with grades K-6, six with grades 7-12, three with the university setting, two with military personnel, and one with adults with special needs. The findings of the research studies are summarized, and its is concluded that: (1) because CAI allows individualized curricula, students generally learn more efficiently; (2) students generally spend more time on CAI lessons involving reading comprehension; and (3) an increase in interest and motivation is almost always assured when CAI is the method of teaching or practicing reading comprehension skills. Four recommendations for use of CAI for reading instruction and further research conclude this study. A 33-item bibliography and a curriculum vitae for the author are also included. (CGD)