This article describes the mechanism through which cultural variability is a source of learning differences. The authors argue that the Universal Design for Learning can be extended to capture the way learning is influenced by cultural variability, and show how the UDL framework might be used to create a curriculum that is responsive to this cultural dimension of learning. When used in this way, the UDL framework may not only reduce barriers for culturally diverse learners, but also increase learning opportunities for all learners--helping them to develop proficiency in a broader range of expressive, analytic, and cognitive styles that are crucial to success in the twenty-first century.