This experiment investigated the capability for movement and muscle spindle function at successive stages during the development of ischemic nerve block (INB) by pressure cuff. Two male subjects were observed under six randomly ordered conditions. The duration of index finger oscillation to exhaustion, paced at 1.2Hz., was observed on separate days immediately, 5, 10, and 15 minutes following cuff application, and after kinesthetic sense loss (KSL). A control condition observed only reflex responses to sudden flexions and extensions of the relaxed finger at the above times during a single cuff application with no active movement. These reflex responses were also observed before cuff application and following movement on other days. Finger movement persisted for two or more minutes at each interval before KSL, and just under one minute following KSL. Reflexes appeared uninfluenced by cuff application without movement. Following movement during cuff application, reflexes were not found beyond the ten-minute observation. These findings indicate reduced but experimentally useful movement capability following KSL provided the subject rests. The alteration of muscle spindle function following movement before KSL is relevant to studies using INB to study the role of proprioception in skilled movement. (Author)