This article is a response to a number of articles that use a culturally relevant prevention (CRP) approach for ethnic and racial minorities. The reaction is from a research practitioner's viewpoint. The authors argue in favor of determining an operational definition of cultural relevance by implementing prevention services with fidelity in the field and understanding what structural components of CRPs are minimally necessary for the effective operation of the prevention programs. Field personnel also need to identify reliable ways to involve in planning those individuals who represent service recipient characteristics. The article closes with a recommendation that research practitioners pursue an active evaluation agenda aimed at further standardizing and quantifying the effectiveness of CRP strategies for underserved racial and ethnic groups.