This fourth part outlines a strategy for overcoming the limitations of the knowledge system for engineering by combining intellectual maps, preventive approaches, umbrella concepts, and round tables as described in the earlier parts. A discussion of the issues faced by modern medicine illustrates the paradigmatic nature of the diagnosis and prescription made for engineering. The social sciences face mirror-image problems. One response has been the rise of new disciplines such as communications, environmental studies, urban affairs, criminology, and policy studies. To avoid the limitations of discipline-based knowing and doing, a similar strategy for their transformation will have to be implemented. Considerable synergies would result if parallel efforts to transform the present knowledge system were carried out throughout the university. Some suggestions are made as to how this can be supported by organizational and institutional changes. Finally, it is suggested that such a transformation of the university could make a critical and decisive contribution to overcoming the current economic, social, and environmental crises.